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KMID : 0359319900300010113
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Korean Journal of Veterinary Research
1990 Volume.30 No. 1 p.113 ~ p.121
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Effect of yohimbine and 4 - aminopyridine on gastroduodenal transit time in xylazine - pentobarbital - anesthetized dogs
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Abstract
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The present study was undertaken to determine the effect of xylazine-pentobarbital anesthesia on the gastroduodenal transit time of barium sulfate and whether this condition can be antagonized by yohimbine, 4-aminopyridine and yohimbine＋4-aminopyridine in dogs.
Xylazine-pentobarbital anesthesia prolonged the gastroduodenal transit time to 121.50±1.25 minutes compared with 5.25±0.90 minutes of control,
Yohimbine and yohimbine＋4-aminopyridine reversed 121.50±1.25 minutes of transit time of anesthetized dog to 25.25±6.83 and 63.25±15.69 minutes, respectively. 4-aminopyridine alone, 115.75±18.35 minutes, was not effective in reversing the xylazine-pentobarbital-induced prolongation of gastroduodenal transit time.
Yohimbine was the most effective for reversal of xylazine-pentobarbital-induced prolongation of gastroduodenal transit time in dogs.
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